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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described as a focus on the practical aspects of design, including the recruitment process and consent, adhering and the use of standard equipment.

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Pragmatic is a software company, offers a variety of casino games for online gambling platforms. Pragmatic's iGaming solutions are used by the top operators and casinos that are located in the land. The company offers front-end design tools, analysis, promotions, marketing payment systems, security, customer service, and bug reporting. The company also offers a safe environment with high-quality graphics, games and security.

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A pragmatic study that involves a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for pragmatic trials to be reliable and to reduce bias in the results is also essential. A high degree of heterogeneity, however could cause issues with the design of the trial.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market, provides an array of traditional table games such as Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta offer customers an authentic gambling experience, as well as a broad range of virtual betting options. The company also hosts a variety of game shows that make online gambling enjoyable and engaging. Some of these shows are hosted live, while others feature famous personalities in the field.

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The purpose of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually requested by policy makers and practitioners to guide their decision-making. They can be used to determine the causal relationship between an intervention and its effects. However, they should not, be used to replace explanatory studies.

The concept of pragmatism is controversial and there are concerns about whether pragmatic trials should replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the characteristics of a practical trial which includes the recruitment process, the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is an indication that the health sciences community is becoming more acquaint to the issue of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.